Wednesday, April 3, 2013

Verifying that sorghum is a new safe grain for people with celiac disease

Verifying that sorghum is a new safe grain for people with celiac disease [ Back to EurekAlert! ] Public release date: 3-Apr-2013
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Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

Strong new biochemical evidence exists showing that the cereal grain sorghum is a safe food for people with celiac disease, who must avoid wheat and certain other grains, scientists are reporting. Their study, which includes molecular evidence that sorghum lacks the proteins toxic to people with celiac disease, appears in ACS' Journal of Agricultural and Food Chemistry.

Paola Pontieri and colleagues explain that those gluten proteins, present in wheat and barley, trigger an immune reaction in people with celiac disease that can cause abdominal pain and discomfort, constipation, diarrhea and other symptoms. The only treatment is lifelong avoidance of gluten. Sorghum, they note, has emerged as an alternative grain for people with celiac disease. In Western countries, sorghum traditionally has been an animal feed. But in Africa and India, it long has been a food for people. Recently, U.S. farmers have begun producing sorghum hybrids that are a white grain, known as "food-grade" sorghum. The researchers set out to make a detailed molecular determination of whether sorghum contains those toxic gluten proteins.

They describe evidence from an analysis of the recently published sorghum genome, the complete set of genes in the plant, and other sources, that verify the absence of gluten proteins. The authors also report that sorghum has high nutritional value. "Food-grade sorghums should be considered as an important option for all people, especially celiac patients," the report concluded.

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The authors acknowledge funding from the Regione Campania, the Istituto Banco di Napoli - Fondazione and the Compagnia di San Paolo.

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 163,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

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Verifying that sorghum is a new safe grain for people with celiac disease [ Back to EurekAlert! ] Public release date: 3-Apr-2013
[ | E-mail | Share Share ]

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

Strong new biochemical evidence exists showing that the cereal grain sorghum is a safe food for people with celiac disease, who must avoid wheat and certain other grains, scientists are reporting. Their study, which includes molecular evidence that sorghum lacks the proteins toxic to people with celiac disease, appears in ACS' Journal of Agricultural and Food Chemistry.

Paola Pontieri and colleagues explain that those gluten proteins, present in wheat and barley, trigger an immune reaction in people with celiac disease that can cause abdominal pain and discomfort, constipation, diarrhea and other symptoms. The only treatment is lifelong avoidance of gluten. Sorghum, they note, has emerged as an alternative grain for people with celiac disease. In Western countries, sorghum traditionally has been an animal feed. But in Africa and India, it long has been a food for people. Recently, U.S. farmers have begun producing sorghum hybrids that are a white grain, known as "food-grade" sorghum. The researchers set out to make a detailed molecular determination of whether sorghum contains those toxic gluten proteins.

They describe evidence from an analysis of the recently published sorghum genome, the complete set of genes in the plant, and other sources, that verify the absence of gluten proteins. The authors also report that sorghum has high nutritional value. "Food-grade sorghums should be considered as an important option for all people, especially celiac patients," the report concluded.

###

The authors acknowledge funding from the Regione Campania, the Istituto Banco di Napoli - Fondazione and the Compagnia di San Paolo.

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 163,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.

Follow us: Twitter Facebook


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/acs-vts040313.php

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'Monsignor Meth' admits to drug possession charge

HARTFORD, Conn. (AP) ? A suspended Roman Catholic priest accused of making more than $300,000 in methamphetamine sales out of his Connecticut apartment while running an adult video and sex toy shop pleaded guilty Tuesday to a federal drug charge.

Kevin Wallin, 61, of Waterbury, admitted to conspiracy to possess with intent to distribute methamphetamine and was scheduled to be sentenced June 25. The prosecution and defense agreed on a sentence of 11 to 14 years in prison.

Prosecutors said the 61-year-old Wallin had meth mailed to him from co-conspirators in California and sold the drugs out of his Waterbury apartment last year. He also bought an adult video and sex toy shop in North Haven named Land of Oz & Dorothy's Place, apparently to launder the drug money, authorities said.

Wearing a beige prison jumpsuit and sporting a goatee and close-cropped hair, Wallin acknowledged in court that the drug operation involved nearly four pounds of methamphetamine. He said "yes" several times as the judge asked whether he understood the consequences of his plea.

Wallin, former pastor at St. Augustine Parish in Bridgeport, appeared to have no supporters in the courtroom. He was led out of the room in handcuffs and remains detained.

Charges against four other people arrested in the case are pending.

"We're glad to have resolved this part of the case," Connecticut U.S. Attorney David B. Fein said outside the courtroom. "It's a serious conspiracy charge involving a very dangerous drug."

Wallin's public defender, Kelly Barrett, declined to comment.

Dubbed in some media as "Monsignor Meth," Wallin was pastor of St. Augustine Parish for nine years until he resigned in June 2011, citing health and personal reasons. He previously served six years as pastor of St. Peter's Church in Danbury until 2002.

"Msgr. Wallin's guilty plea represents an important step in his coming to terms with his own actions and their impact on others," the Diocese of Bridgeport said in a statement. "It is a difficult moment for all of us but we hope it is also the first step in rebuilding his life. We pray that he moves toward healing and wholeness."

The diocese had suspended him from public ministry last May amid concerns by church officials about a number of problems with Wallin, including sexually inappropriate behavior with other men in the church rectory, Wallace said. Church leaders weren't aware of Wallin's involvement with drugs at the time of the suspension, diocese spokesman Brian D. Wallace said.

Wallace said Wallin now faces the prospect of removal from the priesthood by the Vatican, a process called laicization.

Wallin was arrested in January, and a grand jury indicted him and four other people on drug charges.

An undercover officer bought meth from Wallin six times from Sept. 20 to Jan. 2, paying more than $3,400 in total for 23 grams of the drug, authorities said.

Federal agents said they learned through wiretaps and informants about other sales Wallin was making.

On social media, people couldn't help but compare Wallin with Walter White, the main character on the TV show "Breaking Bad," who was making so much cash that he and his wife bought a car wash to launder their profits.

Also charged in the case were Kenneth Devries of Waterbury; Michael Nelson of Manchester; Chad McCluskey of San Clemente, Calif.; and Kristen Laschober of Laguna Niguel, Calif. Authorities say McCluskey and Laschober were involved in the shipping of methamphetamine to Wallin.

All four of those defendants have pleaded not guilty.

Source: http://news.yahoo.com/suspended-conn-priest-admits-meth-charge-151427977.html

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Tuesday, April 2, 2013

SC's ex-Gov. Sanford clears hurdle in comeback bid

Former South Carolina Gov. Mark Sanford thanks his fiance Maria Belen Chapur as he addresses supporters in Mount Pleasant, S.C., on Tuesday, April 2, 2013, after winning the GOP nomination for the U.S. House seat he once held. Sanford is trying to make a comeback after his political career was derailed four years ago when he disappeared from the state only to return to admit the couple was having an affair. Sanford's wife, Jenny, later divorced him. (AP Photo/Bruce Smith)

Former South Carolina Gov. Mark Sanford thanks his fiance Maria Belen Chapur as he addresses supporters in Mount Pleasant, S.C., on Tuesday, April 2, 2013, after winning the GOP nomination for the U.S. House seat he once held. Sanford is trying to make a comeback after his political career was derailed four years ago when he disappeared from the state only to return to admit the couple was having an affair. Sanford's wife, Jenny, later divorced him. (AP Photo/Bruce Smith)

Former South Carolina Gov. Mark Sanford leaves the voting booth after voting at his precinct in Charleston, S.C., on Tuesday, April 2, 2013. Sanford is facing former Charleston County councilman Curtis Bostic in the Republican runoff for South Carolina's vacant 1st District congressional seat. (AP Photo/Bruce Smith)

Former South Carolina Gov. Mark Sanford answers questions from reporters after voting in Charleston, S.C., on Tuesday, April 2, 2013. Sanford is facing former Charleston County councilman Curtis Bostic in the Republican runoff for South Carolina's vacant 1st District congressional seat. (AP Photo/Bruce Smith)

Former South Carolina Gov. Mark Sanford signs in before voting in Charleston, S.C., on Tuesday, April 2, 2013. Sanford is facing former Charleston County councilman Curtis Bostic in the Republican runoff for South Carolina's vacant 1st District congressional seat. (AP Photo/Bruce Smith)

Former Charleston County Councilman Curtis Bostic greets voters at a polling place in Charleston, S.C., on Tuesday, April 2, 1013. Bostic faced former South Carolina Gov. Mark Sanford on Tuesday in the Republican primary runoff for South Carolina's vacant 1st District congressional seat. (AP Photo/Bruce Smith)

(AP) ? Former South Carolina Gov. Mark Sanford on Tuesday cleared another hurdle in his bid for political redemption, defeating a former Charleston County council member to win the GOP nomination for the U.S. House seat he held for three terms.

"It's been a very long journey. And in that journey I am humbled to find ourselves where we find ourselves tonight," said Sanford, whose political career was derailed four years ago when, as sitting governor, he disappeared from the state only to return to acknowledge an extramarital affair with an Argentine woman.

That woman, Maria Belen Chapur, and Sanford are now engaged. She appeared at Sanford's side during his victory speech, smiling and applauding the former governor, who thanked her for being long-suffering while he was campaigning. She did not address the crowd.

"I want to thank my God," Sanford said. "I used to cringe when somebody would say I want to thank my God because at that point I would think this is getting uncomfortable. But once you really receive God's grace and (have) seen it reflected in others you stop and acknowledge that grace and the difference He has made in my life and in so many lives across this state and across this nation."

With all of the precincts reporting Sanford had about 57 percent of the vote in the 1st District to 43 percent for Curtis Bostic, the former county council member. The candidates were vying in the GOP runoff after they finished as the top two vote-getters in a 16-way GOP primary last month.

Sanford will face Democrat Elizabeth Colbert Busch, the sister of comedian Stephen Colbert, and Green Party candidate Eugene Platt in a May special election.

Colbert Busch released a statement late Tuesday saying "I look forward to a vigorous campaign that focuses on creating jobs, balancing our country's budget and choosing an independent-minded leader who shares the values of the great people of South Carolina."

Sanford, a former three-term congressman and two-term governor, said earlier Tuesday that the runoff would give a good indication whether voters have moved past his personal indiscretions.

"I'm both humbled and grateful for the response of the voters here tonight," he said later.

Sanford was a rising Republican political star before he vanished from South Carolina for five days in 2009. Reporters were told he was hiking the Appalachian Trail, but the then-married governor later tearfully acknowledged he was visiting Maria Belen Chapur, which he told everyone at a news conference announcing his affair. He later called her his soul mate and the two were engaged earlier last year.

After the revelation of the affair, Sanford's wife Jenny divorced him and wrote a book.

Before leaving office as governor, Mark Sanford avoided impeachment but was censured by the Legislature over state travel expenses he used for the affair. He also had to pay more than $70,000 in ethics fines ? still the largest in state history ? after Associated Press investigations raised questions about his use of state, private and commercial aircraft.

The opening for Sanford came after U.S. Rep. Tim Scott was appointed to fill the remaining two years of U.S. Sen. Jim DeMint's seat. DeMint resigned to head The Heritage Foundation, a conservative think tank.

Mark Sanford knows the 1st District well. Elected to the seat in 1994 ? Jenny Sanford managed his first campaign and was a close adviser for most of his career ? he served three terms before voters elected him governor in 2002.

Jenny Sanford briefly looked at mounting a race in the Republican-leaning congressional district along the state's southern coast, but she decided against it, saying her job as a mother to the couple's four sons was more important.

In last month's GOP primary, Bostic collected only about 13 percent of the vote, narrowly defeating state Sen. Larry Grooms for second place. But he had less than two weeks to overcome Sanford's high name recognition.

During a televised debate, he took a jab at Sanford, saying "a compromised candidate is not what we need" in the race against Colbert Busch.

Sanford acknowledged he "failed very publically" but said he had done a lot of soul searching since then. He added, "Not since Jesus Christ was here has there been a perfect man or woman."

He said that after Scott was appointed, people kept encouraging him to run.

Sanford said they told him "here is your chance for you to learn, not only from your experience in Congress and the governorship, but more significantly what you learned both on the way up and the way down and apply it to what is arguably one of the great conundrums of our civilization, which is how do we get our financial house in order."

One of those in attendance at the debate was Barbara Boilston, a 49-year-old paralegal from Charleston. She talked about Sanford's indiscretions.

"I believe he has come full circle," she said. "I believe he has found peace with God. If God forgives, I forgive, and we should go forward and put this man back in office."

Bostic said earlier Tuesday that he liked his chances as he visited with voters in a suburban Charleston precinct.

"People dismiss us," the attorney and retired Marine said. "But we believe strongly the best way to win elections is through relationships and we have worked really hard to do that."

Bostic himself did not vote in the GOP runoff on Tuesday because he can't.

His residence near Ravenel, S.C., is in the 6th Congressional District, represented by U.S. Rep. Jim Clyburn, about 1,500 yards from the 1st District line. Bostic's law office, other property, church and children's schools are in the district. Under federal law, to run for the U.S. House, one only need to be a resident of the state in which the district is located, not the district itself.

Associated Press

Source: http://hosted2.ap.org/apdefault/89ae8247abe8493fae24405546e9a1aa/Article_2013-04-02-1st%20District%20Primary%20Runoff/id-c40c653adb754ebdb62ee3b22c615811

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Elmo: Now Voiced By New Actor/Actress!

Source: http://www.thehollywoodgossip.com/2013/04/elmo-now-voiced-by-new-actor/

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Syria accuses rebels of setting fire to oil wells

BEIRUT (AP) ? Heavy shelling in a neighborhood in the northern city of Aleppo sent civilians fleeing for their lives on Sunday, and the state news agency accused rebels trying to topple the government of setting fire to three oil wells.

Syria's civil war has battered the country's infrastructure and torn its social fabric. After more than two years of conflict, neither President Bashar Assad's regime nor the rebels fighting for his ouster appear close to victory.

The Britain-based Syrian Observatory for Human Rights said civilians were vacating the Sheikh Maqsoud neighborhood of Aleppo under heavy shelling by government forces. Rebels took over parts of the neighborhood late last week and were still clashing with Assad's troops who are trying to push them out. The Observatory, which relies on a network of contacts inside Syria, said four people, including two children, were killed in the shelling.

In the east, the state news agency, SANA, said rebels had set fire to three oil wells in the province of Deir al-Zour, causing a daily loss of 4,670 barrels of oil and 52 cubic meters of natural gas. It accused "terrorists," the government's term for rebels, of setting the fires after fighting among themselves about how to divide the oil.

Rebels battling Assad have seized large areas of territory in Syria's oil-rich east, including a number of oil fields. Although they lack the ability to exploit them, their loss represents a setback to the cash-strapped government they are trying to overthrow.

SANA said rebels have burned a total of nine wells in recent months. The three set ablaze on Sunday are the only ones still burning.

Also on Sunday, the government and the opposition blamed each other for killing a group of people found dead near the Lebanese border.

The Observatory said the bodies of 11 people, including eight women, were found near the town of Talkalakh in Homs province. The group said they were killed when government forces stormed the area. But SANA blamed rebels for the "massacre," saying they stormed the area, killed 10 people and looted homes and shops.

In another development, the head of the Syrian opposition's umbrella body said the group's military chief planned to visit Arab countries to solicit military aid. The trip follows a declaration last week by the Arab League that its member nations have a "right" to aid the Syrian opposition. Mouaz al-Khatib, the head of the Syrian National Coalition, told the Qatari daily Al Sharq of Gen. Salim Idris's travel plans, but did not say which countries he would visit.

Syria's conflict began in March 2011 with protests calling for Assad's ouster. It has since become a civil war, with hundreds of independent rebel groups across Syria fighting Assad's forces. The government says the war is an international conspiracy to weaken Syrian being carried out by terrorists on the ground. The U.N. says more than 70,000 people have been killed.

___

Associated Press writers Albert Aji in Damascus, Syria, and Brian Murphy in Dubai, United Arab Emirates, contributed to this report.

Source: http://news.yahoo.com/syria-accuses-rebels-setting-fire-oil-wells-142049239.html

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Monday, April 1, 2013

Unboxing the OUYA (video)

With Kickstarter backer shipments kicking off last Thursday, it's no surprise that some folks are already receiving their OUYA consoles. Two of our US-based, East Coast staffers just got their consoles this morning, and here we are with an unboxing video and screens so that you can share in the excitement with us. Of course, we'll have a full review of the Android-powered $99 game console coming later this week -- long before the console becomes available at retail on June 4th -- so keep your eyes loose and your brains ready. For now, enjoy the melange of media we've prepared for you; should you prefer a deeper dive, our hands-on is right here.

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Source: http://www.engadget.com/2013/04/01/ouya-unboxing/

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Early COPD diagnosis possible with nuclear medicine

Apr. 1, 2013 ? In vivo ventilation/perfusion (V/Q) imaging can detect early changes to the lung caused by cigarette smoke exposure and provides a noninvasive method for studying lung dysfunction in preclinical models, according to research published in the April issue of The Journal of Nuclear Medicine. These measures have the potential to be applied clinically to study and diagnose the early stages of chronic obstructive pulmonary disease (COPD).

COPD is a slow-progressing, debilitating lung disease which is commonly caused by cigarette smoking. Defining characteristics of COPD include chronic inflammation, increased mucus production, small-airway fibrosis and airspace enlargement. Many people with COPD, however, go undiagnosed until their disease has reached a more symptomatic stage and irreversible damage has occurred.

"Better diagnostic tools are needed to detect early changes in smokers to prevent further lung dysfunction and provide patients with individualized treatment regimens," said N. Renee Labiris, PhD, one of the authors of the study "Detection of Lung Dysfunction Using Ventilation and Perfusion SPECT in a Mouse Model of Chronic Cigarette Smoke Exposure." "Our preclinical study suggests that not only can V/Q imaging detect early and small changes in lung pathology, the type of V/Q mismatching could provide insight into the underlying pathologies, which current measures of lung function are unable to do."

In the study, groups of mice were exposed to cigarette smoke for 50 minutes twice daily, five days a week, for either eight or 24 weeks. Age-matched control groups of mice were also included in the study for comparison. After the final cigarette smoke exposure, V/Q single photon emission computed tomography (SPECT) was performed, followed by a computed tomography (CT) scan. Histologic lung sections were then collected and a semiautomated quantitative analysis of airspace enlargement was applied to whole histology slices.

Upon analysis, functional impairment was noted in the lungs due to increased inflammation and airspace enlargement. This functional impairment, measured with SPECT V/Q imaging, identified COPD characteristics before CT was able to detect structural changes in the lungs. In addition V/Q mismatching progressively increased during cigarette smoke exposure in micecompared to age-matched control mice and offered insight into the underlying pathology causing COPD.

"V/Q imaging is a common nuclear medicine technique, and SPECT/CT systems are increasingly used in clinical practice," noted Labiris. "As such, the technology examined in this study can be carried out in both preclinical and clinical settings, enabling researchers to translate preclinical investigations of disease, associated functional abnormalities and future drug targets into an improved understanding and management of the disease in patients."

Authors of the article "Detection of Lung Dysfunction Using Ventilation and Perfusion SPECT in a Mouse Model of Chronic Cigarette Smoke Exposure"include Brian N. Jobse, Departments of Medicine and Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada, and Firestone Institute for Respiratory Health at St. Joseph's Healthcare, Hamilton, Ontario, Canada; Rod G. Rhem and Iris Q. Wang, Department of Medicine, Division of Respirology, McMaster University, Hamilton, Ontario, Canada; William B. Counter and N. Ren?e Labiris, Department of Medicine, Division of Respirology, McMaster University, Hamilton, Ontario, Canada and Firestone Institute for Respiratory Health at St. Joseph's Healthcare, Hamilton, Ontario, Canada; and Martin R. St?mpfli, Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada, and Firestone Institute for Respiratory Health at St. Joseph's Healthcare, Hamilton, Ontario, Canada.

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The above story is reprinted from materials provided by Society of Nuclear Medicine.

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Journal Reference:

  1. B. N. Jobse, R. G. Rhem, I. Q. Wang, W. B. Counter, M. R. Stampfli, N. R. Labiris. Detection of Lung Dysfunction Using Ventilation and Perfusion SPECT in a Mouse Model of Chronic Cigarette Smoke Exposure. Journal of Nuclear Medicine, 2013; 54 (4): 616 DOI: 10.2967/jnumed.112.111419

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/O3rZmgTl_xs/130401111549.htm

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